abstract：:Recently it was observed that the hypothyroid state induced by propylthiouracil treatment reduced the elimination rate of ethanol. This was based on the fact that hypothyroid rats could only tolerate 10 g/kg/day of ethanol infusion over 24 h. Euthyroid rats tolerate 13 to 14 g/kg/day of ethanol infusion. In the presen...

journal_title：Experimental and molecular pathology

authors： Li J,French BA,Fu P,French SW

更新日期：2001-08-01 00:00:00

abstract：:In the erythrocyte, ankyrin is the major adapter protein linking tetramers of band 3 to the spectrin-actin cytoskeleton. This linkage involves a direct interaction between ankyrin and the 14th-15th repeat unit of beta-spectrin. The spectrin cytoskeleton itself is stabilized by the self-association of spectrin heterodi...

journal_title：Experimental and molecular pathology

authors： Giorgi M,Cianci CD,Gallagher PG,Morrow JS

更新日期：2001-06-01 00:00:00

abstract：:Vascular endothelium is a major target of actions of the proinflammatory cytokine tumor necrosis factor (TNF). Increasingly, the intracellular pathways that are activated in response to TNF have been elucidated. Many of these pathways have proven to be cell type-specific, requiring that observations made in other cell...

journal_title：Experimental and molecular pathology

authors： Madge LA,Pober JS

更新日期：2001-06-01 00:00:00

abstract：:Macrophages play an essential role in pulmonary host defense. They are, however, a heterogeneous cell population located in different lung compartments. This study was designed to elucidate differences between two macrophage populations obtained from the human lung, i.e., alveolar macrophages (AM) and interstitial mac...

journal_title：Experimental and molecular pathology

authors： Fathi M,Johansson A,Lundborg M,Orre L,Sköld CM,Camner P

更新日期：2001-04-01 00:00:00

abstract：:Kidney aging has been recognized as a chronic process of compromised renal function and structural changes in the tubulointerstitium and glomerulus. Cell senescence is associated with alterations in cell structure and function, including expression of cytokines and structural and regulatory components of extracellular...

journal_title：Experimental and molecular pathology

authors： Ding G,Franki N,Kapasi AA,Reddy K,Gibbons N,Singhal PC

更新日期：2001-02-01 00:00:00

abstract：:The CXC chemokine receptor CXCR4 was the first molecule identified as a coreceptor working in conjunction with CD4 to mediate cellular entry for the human immunodeficiency virus (HIV-1). Since that original discovery, 11 other seven-mtransmembrane domain molecules, many of which are chemokine receptors, have been show...

journal_title：Experimental and molecular pathology

authors： van der Meer P,Ulrich AM,Gonźalez-Scarano F,Lavi E

更新日期：2000-12-01 00:00:00

abstract：:Thirty-nine patients with fibromyalgia syndrome (FMS) according to American College of Rheumatology criteria were studied for cell-mediated sensitivity to environmental chemicals. Lymphocytes were tested by standard [(3)H]thymidine incorporation in vitro for T cell memory to 11 chemical substances. Concanavalin A (Con...

journal_title：Experimental and molecular pathology

authors： Shanklin DR,Stevens MV,Hall MF,Smalley DL

更新日期：2000-10-01 00:00:00

abstract：:RAK antigens p120, p42, and p25 exhibit molecular and immunological similarity to the proteins encoded by HIV-1 and are expressed by 95% of breast and gynecological cancer cases in women and prostate cancer cases in men. Binding of the monoclonal antibody (MAb) RAK-BrI to cancer RAK antigens has been found to be inhib...

journal_title：Experimental and molecular pathology

authors： Kyriacou KC,Iacovou F,Adamou A,Hadjisavvas A,Rakowicz-Szulczynska EM

更新日期：2000-08-01 00:00:00

abstract：:Retinoids are known to modulate macrophage differentiation, proliferation, and function including cytokine gene expression. However, signaling of retinoic acid (RA), a biologically active metabolite of vitamin A, in Kupffer cells has not been characterized. This study reports mRNA expression by rat Kupffer cells of RA...

journal_title：Experimental and molecular pathology

authors： Ohata M,Yamauchi M,Takeda K,Toda G,Kamimura S,Motomura K,Xiong S,Tsukamoto H

更新日期：2000-02-01 00:00:00

abstract：:The amelioration of fetal alcohol effects on the postnatal development of the Purkinje cell by exogenous L-thyroxine was investigated in the neonatal rat. Time-pregnant rats were divided into three groups. Group A (n = 6) received 35% liquid ethanol diet; Group B (n = 6) was fed a liquid diet in which maltose dextrins...

journal_title：Experimental and molecular pathology

authors： Nathaniel EJ,Hassard T,Burton L,Novak C

更新日期：1999-12-01 00:00:00

abstract：:In this comparative study, rat hearts were perfused at 37 degrees C with three clearly defined protocols: the Ca2+ paradox, the O(2) paradox, and with 20 mM caffeine. Each protocol involved an initial priming (Ca(2+)(0) depletion or anoxia; stage 1) and subsequent full activation (Ca(2+)(0) repletion, caffeine or reox...

journal_title：Experimental and molecular pathology

authors： Harding RJ,Duncan CJ

更新日期：1999-10-01 00:00:00

abstract：:A large surgical wound is required for implantation of silicone mammary devices. Formation of capsules around silicone devices follows wound healing processes except that the healing is conformed and significantly delayed by the physical presence of the implant. Multilayered capsules are thicker and lymphocytic and pl...

journal_title：Experimental and molecular pathology

authors： Shanklin DR,Smalley DL

更新日期：1999-09-01 00:00:00

abstract：:Partial-thickness skin burns have been shown to induce neutrophil-dependent microvascular injury both locally (skin) and systemically (lung). In the present study, interventional measures to block inflammatory chemoattractants were employed to define the pathophysiologic role of these mediators in the development of s...

journal_title：Experimental and molecular pathology

authors： Piccolo MT,Wang Y,Sannomiya P,Piccolo NS,Piccolo MS,Hugli TE,Ward PA,Till GO

更新日期：1999-08-01 00:00:00

abstract：:We cloned and partially characterized a human endonuclease (Xib) which shows sequence homologies to pancreatic DNase I but an enzymatic activity closer to DNase II. We report on the structural differences found between Xib and other recently cloned human DNases. Fluores cence microscopy analysis of transiently transfe...

journal_title：Experimental and molecular pathology

authors： Malferrari G,Mazza U,Tresoldi C,Rovida E,Nissim M,Mirabella M,Servidei S,Biunno I

更新日期：1999-06-01 00:00:00

abstract：:DNA isolated from the culture of an African green monkey simian cytomegalovirus (SCMV)-derived stealth virus has been cloned. A region of the virus that contains genes coding proteins homologous to the UL141, UL144, and UL145 proteins of human cytomegalovirus has recombined with cellular sequences encoding several dis...

journal_title：Experimental and molecular pathology

authors： Martin WJ

更新日期：1999-04-01 00:00:00

abstract：:Heritable differences in tumor susceptibility are observed in mice after repetitive exposures to the organotropic colon carcinogen azoxymethane (AOM). The following study was undertaken to determine whether early morphological alterations within the colonic epithelium correlate with subsequent cancer risk. A/J and SWR...

journal_title：Experimental and molecular pathology

authors： Delker DA,Wang QS,Papanikolaou A,Whiteley HE,Rosenberg DW

更新日期：1999-02-01 00:00:00

abstract：:Drug-primed mice form Mallory bodies in their liver after various types of liver injury such as heat shock, drug refeeding, or ethanol ingestion. However, the mechanisms involved that lead to Mallory body formation after these different treatments are unknown. There may be a common pathway of Mallory body formation th...

journal_title：Experimental and molecular pathology

authors： Yuan QX,Nagao Y,Gaal K,Hu B,French SW

更新日期：1998-10-01 00:00:00

abstract：:The dialysate fluid of uremic patients exhibits, in vitro, an inhibitory effect on cell growth, owing to urea, guanidino compounds, and substances named middle molecules. The polyamines are compounds which exhibit high levels in biological fluids during either normal development or disease such as psoriasis, uremia, a...

journal_title：Experimental and molecular pathology

authors： Stabellini G,Mariani G,Pezzetti F,Calastrini C

更新日期：1997-01-01 00:00:00

abstract：:Diabetic patients are at greater risk for restenosis following angioplasty, but the mechanisms involved remain unclear. Early proliferative changes in vessels following angioplasty contribute to the subsequent intimal thickening associated with restenosis. Materials released from platelets which interact with the inju...

journal_title：Experimental and molecular pathology

authors： Winocour PD,Hryhorenko L

更新日期：1995-12-01 00:00:00

abstract：:We have modified methods of growing human gallbladder epithelial cells in monolayer and organotypic culture. These cells were grown in the presence of fetal bovine serum and with coculture of feeder layers of human gallbladder fibroblasts. Human gallbladders were obtained from cholecystectomy specimens, and the cells ...

journal_title：Experimental and molecular pathology

authors： Oda DP,Eng L,Savard CE,Newcomer M,Haigh WG,Lee SP

更新日期：1995-08-01 00:00:00

abstract：:Previous studies demonstrated that more electronegative low density lipoprotein (LDL) isolated from human blood by ion exchange chromatography has a chemical composition and physical properties similar to desialylated LDL obtained by lectin chromatography (Avogaro et al., 1988; Orekhov et al., 1989). In this study, si...

journal_title：Experimental and molecular pathology

authors： Tertov VV,Bittolo-Bon G,Sobenin IA,Cazzolato G,Orekhov AN,Avogaro P

更新日期：1995-06-01 00:00:00

abstract：:Previous studies demonstrated that the anti-phosphorylcholine (PC) antibodies produced by aged BALB/c (18-22 months old) mice are structurally different and less protective against infection with Streptococcus pneumoniae than those produced by young (3-4 months old) syngeneic mice. However, PC antibody from aged anima...

journal_title：Experimental and molecular pathology

authors： Nicoletti C

更新日期：1995-04-01 00:00:00

abstract：:We used the intragastric feeding rat model for alcoholic liver disease to evaluate the relationship among intercellular adhesion molecule-1 (ICAM-1) expression, tumor necrosis factor-alpha (TNF-alpha), plasma endotoxin, and inflammatory changes in the liver. Rats were fed different dietary fats (saturated fat, corn oi...

journal_title：Experimental and molecular pathology

authors： Nanji AA,Griniuviene B,Yacoub LK,Fogt F,Tahan SR

更新日期：1995-02-01 00:00:00

abstract：:CD44 is a polymorphic family of immunologically related integral membrane glycoproteins associated with cell matrix adhesion, lymphocyte activation and targeting, and tumor growth and metastasis. We studied CD44 expression in 114 formalin-fixed paraffin-embedded thyroid tumors using the A3D8 anti-human CD44 monoclonal...

journal_title：Experimental and molecular pathology

authors： Figge J,del Rosario AD,Gerasimov G,Dedov I,Bronstein M,Troshina K,Alexandrova G,Kallakury BV,Bui HX,Bratslavsky G

更新日期：1994-12-01 00:00:00

abstract：:The thrombocyte is the avian equivalent of the mammalian blood platelet and is involved in hemostasis through a fibrinogen-mediated process. Although fibrinogen has been implicated as a molecular bridge between activated cells during aggregation, the location of this molecule and its receptor on thrombocytes has not b...

journal_title：Experimental and molecular pathology

authors： O'Toole ET,Hantgan RR,Lewis JC

更新日期：1994-12-01 00:00:00

abstract：:Histoquantitative methods were applied to study the changes of splenic structure and proportions of splenic tissue compartments in cisplatin-treated (6 mg/kg body wt) male Wistar rats. Six days after treatment the significant reduction of volume density of white pulp was observed, which was due to the very prominent d...

journal_title：Experimental and molecular pathology

authors： Milićević Z,Slepcević V,Nikolić D,Zivanović V,Milićević NM

更新日期：1994-10-01 00:00:00

abstract：:In the present investigation, we observed that lead in vitro activates calmodulin at lower concentrations, and the maximum activation was observed at 30 microM concentration. In vivo lead exposure (50 mg/kg body weight, intragastrically) for a period of 8 weeks also stimulated the activity of calmodulin by 45%. The ad...

journal_title：Experimental and molecular pathology

authors： Sandhir R,Gill KD

更新日期：1994-08-01 00:00:00

abstract：:The present study was undertaken to examine a possible effect of aprotinin, a 6.5-kDa polypeptide with an inhibitory effect on proteolysis, on aminoglycoside nephrotoxicity. Experimental animals (female Sprague-Dawley rats, 175-200 g body wt) were treated for 4 days with 40 mg/kg gentamicin given ip at 12-hr intervals...

journal_title：Experimental and molecular pathology

authors： Morin NJ,Frau A,Nonclercq D,Toubeau G,Zanen J,Heuson-Stiennon JA,Bergeron MG,Beauchamp D,Laurent G

更新日期：1994-06-01 00:00:00

abstract：:The purpose of this study was to better establish the morphologic basis of the early mucosal lesions of experimental inflammatory bowel disease because understanding the development of these lesions has important pathogenetic implications. Sprague-Dawley rats were given 1.5% hydrolyzed lambda-carrageenan orally for 30...

journal_title：Experimental and molecular pathology

authors： Moyana TN,Xiang J,Qi Y,Kalra J

更新日期：1994-04-01 00:00:00

abstract：:It is known that spermidine and other naturally occurring polyamines accumulate in rat lung slices by an energy-dependent uptake process and that alveolar macrophages (AM) have a greater rate of uptake than has the total lung cell population. In the present study rat AMs were incubated with spermidine, which resulted ...

journal_title：Experimental and molecular pathology

authors： Bulychev AG,Johansson A,Lundborg M,Camner P,Afzelius BA

更新日期：1994-02-01 00:00:00

abstract：:The effect of fish oil supplements on atherogenesis is controversial, especially when fish oil does not lower plasma cholesterol. Some studies in swine have shown that a fish oil supplement to a butter-cholesterol diet reduces atherogenesis. The fish oil supplement also frequently reduces average plasma cholesterol le...

journal_title：Experimental and molecular pathology

authors： Schmee J,Kim DN,Ross JS,Thomas WA

更新日期：1993-12-01 00:00:00

abstract：:The Chediak-Higashi syndrome (CHS) is an inherited disorder of humans and of several animal species, characterized by partial albinism, pseudohemophilia, increased susceptibility to disease, and large inclusions in all granule-forming cells. In this study, various parameters of adenine nucleotide biochemistry were exa...

journal_title：Experimental and molecular pathology

authors： Jamison KC,Padgett GA,Giesy JP,Bell TG

更新日期：1993-02-01 00:00:00

abstract：:We studied the effects of clentiazem, a calcium channel blocker (1) on the accumulation of lipid in the aorta, (2) on the level of plasma lipids, and (3) on the number of adherent intimal monocytes and foam cells. Seventy Wistar rats were assigned to one of the following groups: (1) regular diet, (2) an atherogenic di...

journal_title：Experimental and molecular pathology

authors： Nunnari JJ,Fisher M,White SD

更新日期：1992-12-01 00:00:00

abstract：:In vivo and in vitro studies performed on the polar solvent N-methylformamide (NMF), as well as on its association with chemotherapeutic agents or X rays, have clearly demonstrated that this compound is capable of inducing changes in biological characteristics of tumor cells, e.g., cell differentiation. However, the m...

journal_title：Experimental and molecular pathology

authors： Malorni W,Meschini S,Arancia G

更新日期：1992-10-01 00:00:00

abstract：:Reproductive performances of female hamsters were investigated during Ancylostoma ceylanicum (hookworm) infection. Animals having the highest levels of infection (34.96 +/- 1.11 worms) showed degenerative changes in the reproductive system. Ovaries of infected animals contained a few primary or secondary follicles. On...

journal_title：Experimental and molecular pathology

authors： Gupta S,Srivastava JK,Malaviya B,Katiyar JC

更新日期：1992-08-01 00:00:00

abstract：:Dibasic esters (DBE) solvent has been demonstrated to induce a mild degeneration of the olfactory, but not the respiratory epithelium of the rat nasal cavity following a 90-day inhalation exposure. Previous work has demonstrated that acid phosphatase release is a reliable index of DBE-induced cytotoxicity in an in vit...

journal_title：Experimental and molecular pathology

authors： Trela BA,Frame SR,Bogdanffy MS

更新日期：1992-06-01 00:00:00

abstract：:The effect of dichlorvos exposure (5 mg kg-1 body wt, ip) on lipid peroxidation and antioxidant defense system in different regions of the rat central nervous system was studied. In the present paper an inhibition of acetylcholinesterase activity was used as an index of dichlorvos neurotoxicity. We observed significan...

journal_title：Experimental and molecular pathology

authors： Julka D,Pal R,Gill KD

更新日期：1992-04-01 00:00:00

abstract：:It is thought that regeneration of the liver provides a state of preparedness for the Shwartzman reaction and contributes to the development of endotoxin-associated massive hepatic necrosis following partial hepatectomy. Therefore we examined endotoxin hepatotoxicity in rats with hepatic regeneration after 35% hepatec...

journal_title：Experimental and molecular pathology

authors： Shibayama Y,Asaka S,Nishijima A,Nakata K

更新日期：1992-02-01 00:00:00

abstract：:During short term culture of murine resident peritoneal macrophages, increasing the temperature from 37 to 39 degrees C resulted in an increased activity of several surface receptors (FcR and receptor for gluteraldehyde-fixed sheep red blood cells), enhanced phagocytosis of yeast particles, improved spreading, and an ...

journal_title：Experimental and molecular pathology

authors： van Bruggen I,Robertson TA,Papadimitriou JM

更新日期：1991-10-01 00:00:00

abstract：:The extracellular localizations of urokinase-type plasminogen activator (uPA), tissue-type plasminogen activator (tPA), and plasminogen activator inhibitor-1 (PAI-1) were examined in cultured bovine capillary endothelial cells (BCEs) by an immunofluorescence method using BCEs treated with or without saponin and focal ...

journal_title：Experimental and molecular pathology

authors： Murata T,Nakashima Y,Yasunaga C,Maeda K,Sueishi K

更新日期：1991-10-01 00:00:00